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Products Description
IGF LR3 is a structurally modified insulin-like growth factor, possessing an amino acid structure different from native IGF-1. It has 13 additional amino acids at the N-terminus and a substitution at the 3rd amino acid, which reduces its binding affinity to insulin-like growth factor binding proteins.
It can bind to specific receptors on the cell surface and participate in regulating cell growth, survival, protein synthesis and glucose metabolism. Compared with native IGF-1, it features a longer duration of biological activity, and its specific effects are affected by cell types and physiological environments.
Product Applications
Development of serum-free cell culture systems
In in vitro cell culture experiments, it serves as a growth factor additive to optimize the cell growth environment, improve cell attachment, reduce reliance on serum supplements, and suit the expansion and culture of various engineered cell lines.
Biological research on skeletal muscle cells
IGF LR3 can act on specific receptors on the surface of muscle cells. It is often used to construct in vitro skeletal muscle cell models to observe the processes of cell proliferation and differentiation, and analyze the biological changes brought by peptide signals to the metabolic state of muscle cells.
Exploration of growth regulation mechanisms of osteocytes
Applied in in vitro experiments related to osteocytes, it is used to study how peptide signals regulate osteocyte activity and observe the synthesis of cellular matrix, providing experimental material support for basic experiments related to bone growth.
Investigation of cellular glucose metabolism signaling pathways
With cell and animal models, research on glucose uptake and energy metabolism is carried out to observe the regulatory effects of peptide signals on intracellular protein synthesis and nutrient distribution, and analyze the relevant metabolic regulation logic.
How to Use
Reconstitution: Add 1 mL of 100 mM acetic acid to 1 mg of IGF LR3 lyophilized powder to prepare a 1 mg/mL stock solution; mix gently, do not shake vigorously, aliquot for storage and avoid repeated freeze-thaw cycles.
Working concentration for cell experiments: 10–100 ng/mL, commonly starting at 50 ng/mL.
Reference dosage for animal models: Subcutaneous administration at 100–300 μg/kg, once every 48–72 hours; 25–50 μg per local site.
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