QHY Bioengineering Co., Ltd. is one of the leading manufacturers and suppliers of p21 peptide in China. We are committed to providing high quality customized products with competitive price. If you're going to wholesale bulk durable p21 peptide, welcome to get quotation and free sample from our factory.
Product Description
P21 peptide, also known as P021, is a synthetic modified peptide derived from ciliary neurotrophic factor (CNTF). It antagonizes LIF signaling pathways and up‑regulates BDNF expression to promote hippocampal neurogenesis and inhibit tau hyperphosphorylation, delivering neuroprotective effects. Chemical modification improves its blood‑brain‑barrier permeability and avoids side effects associated with full‑length CNTF.
Supplied as lyophilized powder in vials, it is widely used in pre‑clinical research covering neurodegeneration, brain injury and age‑related cognitive decline. For research‑only purposes and not for human therapeutic use.
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Product Name |
P21 Peptide |
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Type |
Vials/Capsules/Drops/Powder/or Customizable |
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Service |
OEM/ODM/Private Label |
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MOQ |
Non-customized products: 1 box; Customized products: Subject to circumstances |
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Sample |
Samples available upon request |
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Shelf life |
2-5 years |
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Storage |
Cool and dry |
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Package size |
30*30*35cm/50pcs or customer's requirements |
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Payment method |
USDT, Alipay, Bank Transfer, Bitcoin |
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Packaging Options |
Bulk , bottles , blister packs or customers' requirement |
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Shipping |
DHL , Fedex , UPS , EMS , TNT , by Sea , by air |
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Delivery Time |
5-15 days after your order is confirmed |
Product Advantages
Excellent blood-brain barrier penetration ability: After chemical modification, peripheral administration can cross the blood-brain barrier and act on brain targets, overcoming the shortcoming that most neurotrophic factors are difficult to enter the brain, making it more suitable for brain-related research. this makes it highly suitable for brain-related research.
Avoids side effects associated with full-length CNTF: Derived from a modified CNTF peptide, it retains neuroprotective and proneurogenic activities while eliminating the adverse reactions caused by full-length CNTF, demonstrating a favorable safety profile in animal studies.
Multiple neuroprotective mechanisms: P21 peptide upregulates BDNF expression, promotes hippocampal neurogenesis, and inhibits tau hyperphosphorylation while enhancing synaptic plasticity; it is applicable to research models involving cognitive decline, brain injury, and neurodegeneration.
High peptide stability: Terminal chemical modifications enhance resistance to enzymatic degradation, preventing rapid breakdown by endogenous proteases; as a chemically synthesized peptide, it offers defined and uniform composition, ensuring superior batch-to-batch consistency compared to animal-derived peptide extracts and facilitating experimental reproducibility.
FAQ
1. How should it be stored?
Store unopened lyophilized powder at -20°C in a dry place, protected from light, and avoid repeated freeze-thaw cycles. After reconstitution, it is recommended to aliquot the peptide solution into single-use portions and store them at -20°C; ideally, prepare and use immediately, as high temperatures can cause peptide inactivation and aggregation.
2. What solvent should be used for reconstitution?
Sterile ultrapure water or PBS buffer is generally suitable for reconstitution; the use of strongly acidic or strongly alkaline solvents is not recommended. Brief, intermittent sonication may be used to assist dissolution, but avoid prolonged, high-power sonication to prevent peptide degradation.
3. What is the shelf life of the reconstituted peptide solution?
When stored at 2–8°C, it is recommended to use the solution within 28 days; for in vivo animal experiments requiring high biological activity, use within 7–14 days. Aliquoting and storing at -20°C can extend the shelf life, whereas repeated freeze-thaw cycles will significantly reduce the peptide's biological activity.
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