Pnc Peptide

QHY Bioengineering Co., Ltd. is one of the leading manufacturers and suppliers of pnc peptide in China. We are committed to providing high quality customized products with competitive price. If you're going to wholesale bulk durable pnc peptide, welcome to get quotation and free sample from our factory.

Pnc peptide is a synthetic peptide composed of two joined segments. One segment is derived from the human tumor-suppressor protein p53 and is capable of recognizing and binding to the HDM-2 target, the other is a cell-penetrating peptide fragment that facilitates approach to the cell membrane, enabling targeted recognition.

The research rationale behind PNC-27 is distinctive: it primarily targets the HDM-2 protein, which is highly expressed on the surface of cancer cell membranes, upon binding, it creates pores in the membrane, thereby disrupting its structural integrity.

These are fundamental research topics conducted at the cellular and animal levels, intended solely for reference:

1. Selective killing of tumor cells
This is the core area of research. Studies leverage specific differences to observe whether PNC-27 can precisely identify cancer cells, disrupt their cell membranes, and induce lytic death while minimizing harm to normal cells. Breast cancer, cervical cancer, pancreatic cancer, and leukemia cells are frequently used as research models in the literature.

2. p53-independent anti-tumor research
Many traditional targeted therapies require cancer cells to possess a functional p53 gene to be effective. However, PNC-27 operates via a different mechanism; it can induce cancer cell lysis even when p53 is mutated or non-functional, making it suitable for exploring drug-resistant tumor models.

3.Synergistic effects of combination therapy

Many research teams combine pnc peptide with other anti-tumor agents to observe whether the combination enhances the inhibition of cancer cells and to explore new therapeutic strategies.

4. Research on cell membrane protein targets
This area focuses on investigating the function of HDM-2 protein on the cell membrane, protein-protein interactions, and the formation of transmembrane pores, making it suitable for fundamental experiments in cell biology and membrane biology.
 

Pnc peptide is supplied as a lyophilized powder in glass vials. Each package contains 10 vials housed in a plastic box. For shipment, we wrap the package in shock-absorbing protective film to provide comprehensive cushioning, minimizing the risk of damage during transit and ensuring the product arrives safely.

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